PURINE NUCLEOTIDE METABOLISM IN HUMAN NEUROBLASTOMA CELL LINES: 99
نویسندگان
چکیده
منابع مشابه
Purine and pyrimidine nucleotide metabolism in Mollicutes
Several mollicute genome projects are underway, offering unique opportunities to study genes and metabolic pathways on a genome-wide scale. Here, we have analyzed the conservation and diversity of purine and pyrimidine metabolism in mycoplasmas. An evaluation of discrepancies between genomic analysis and enzymatic data revealed interesting aspects about these organisms. We found important examp...
متن کاملLymphocyte maturation in the human thymus. Relevance of purine nucleotide metabolism for intrathymic T cell function.
The combination of centrifugal elutriation as an efficient and reproducible method to separate thymocytes by size, micromethods to assess purine interconversion enzymes, and assessment of purine (deoxy)nucleoside inhibition of mitogen responses enabled us to study purine metabolism at the intrathymic level. Out of six fractions, four (nos. 3-6), containing medium- and large-sized lymphocytes, s...
متن کاملEffects of purine nucleotide administration on purine nucleotide metabolism in brains of heroin-dependent rats
Heroin is known to enhance catabolism and inhibit anabolism of purine nucleotides, leading to purine nucleotide deficiencies in rat brains. Here, we determined the effect of exogenous purine nucleotide administration on purine nucleotide metabolism in the brains of heroin-dependent rats. Heroin was administrated in increasing doses for 9 consecutive days to induce addiction, and the biochemical...
متن کاملPurine and pyrimidine nucleotide synthesis and metabolism.
1. Abstract 2. Introduction 3. Purine and pyrimidine metabolism during somatic embryogenesis 3.1. Maintenance of embryogenic tissue 3.1.1. Purine metabolism during maintenance of embryogenic tissue 3.1.2. Pyrimidine metabolism during maintenance of embryogenic tissue 3.2. Development of somatic embryos 3.2.1. Purine metabolism during development of somatic embryos 3.2.2. Pyrimidine metabolism d...
متن کاملPurine metabolism in normal and thioguanine-resistant neuroblastoma.
Purine metabolism has been examined in a clonal line of mouse neuroblastoma cells resistant to the cytotoxic effects of 6-thioguanine. Comparative studies in the resistant and parental lines indicate that the former cells have less than 1% of normal hypoxanthine phosphoribosyltransferase (EC 2.4.2.8) activity. The activities of other enzymes important in the de novo and salvage pathways of puri...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Pediatric Research
سال: 1985
ISSN: 0031-3998,1530-0447
DOI: 10.1203/00006450-198507000-00119